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KMID : 1144820190250020113
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대한의생명과학회지
2019 Volume.25 No. 2 p.113 ~ p.122
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Beyond X-Chromosome Inactivation: The Oncogenic Facet of XIST in Human Cancers
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Madhi Hamadi
Kim Myoung-Hee
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Abstract
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Long-non coding RNAs (LncRNAs) constitute a wide and extremely diverse family of RNA transcripts that are greater than 200 base pairs in length and are not translated into proteins. X-inactive specific transcript (XIST) was the first long non-coding RNA to be discovered, back in 1991. Its function in X-chromosome inactivation has been extensively studied for three decades, though other functional roles of XIST that involve a variety of fascinating mechanisms remain to be elucidated. Here, we review the emerging oncogenic role of XIST in various human cancers.
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KEYWORD
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X chromosome inactivation, XIST, LncRNA, CeRNA, Human cancer, miRNA
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